The two sides have met once before, with Juventus playing in Turin on January 1, 2019.
The Bianconeri beat the Red Devils 3-1 in the first leg, and then lost 2-0 to Atalanta on January 15.
Juventus also beat Roma in Rome on February 12, 2018.
The Italian side have a lot of quality in midfield.
Sergio Aguero, Andrea Pirlo, Mario Mandzukic and Miralem Pjanic all scored or assisted for the squad.
Defenders Giorgio Chiellini, Andrea Barzagli, Andrea Soldado and Mario Mandžukić all started the match, while Alessio Romagnoli and Simone Zaza played their first minutes.
Besiktas Lazio have lost three of their last four league games and have only two wins in the league.
They beat AC Milan 1-0 in the Champions League on February 11 and are currently third in the table.
Giorgio Arrigo had a brace and a goal in the win over Juventus.
Real Madrid have beaten Sevilla, Atletico Madrid and Juventus, but are still in the relegation zone.
They have won two of their past three matches and lost two in a row.
Barcelona have won six of their seven league games this season, but have only lost once in six.
Juventus are still searching for their first Champions League win.
Atletico Madrid have lost four of their five league matches and are yet to beat a team outside of the Champions league.
Bayern Munich won their first Bundesliga match in four years on Sunday, 3-2 over Borussia Monchengladbach.
They are currently second in the Bundesliga table.
The German side have won all of their four Champions League games so far, scoring 16 goals.
Cristiano Ronaldo scored a hat-trick in the 2-1 victory over Hoffenheim, the first goal of his career for the club.
Dani Alves scored two goals and made three assists in the 4-0 win over Villarreal.
The Brazilian winger has scored more goals in Champions League than any other player in the competition, with nine goals.